Our research focuses on five key areas:
1. Application of Artificial Intelligence (AI) methods to the processing of biomedical images and the investigation of protein conformational changes
2. QM/MM and Metadynamics simulations of enzymatic reactions
3. Simulation and analysis of coevolution in proteins
4. X-ray crystallography of chaperones of F1F0 ATPase and enzymes involved in polysaccharide biosynthesis
5. Metabolic simulation of bacterial and eukaryotic cells and cellular communities
- Coevolution maps recorded by our Matlab program MSAVOLVE during the in silico evolution of a protein from a hypothetical ancestor.
Domenico L. Gatti MD PhD, School of Medicine of Wayne State University, Scott Hall, 540 E. Canfield Avenue, Detroit, MI 48201 - US