Topics:
- Module 1: Introduction to Python Programming
- Module 2: Linear Algebra and Optimization in Biomedical Modeling
- Module 3: Simulation of Biochemical and Enzymatic Reactions
- Module 4: Metabolic Control Analysis (MCA)
- Module 5: Kinetic Modeling of Drug Metabolism and Disease Progression
- Module 6: Constraint-Based Modeling (CBM) of Cellular Metabolism
- Module 7: Metabolic Network Reconstruction and Precision Medicine
- Module 8: Systems Biology Approaches to Infectious DiseasesModule
- Module 9: Final Project - Metabolic Modeling of Cancer or Infectious Disease to Identify Therapeutic Targets
Students, individually or in groups, will carry out a Final Project that will combines systems biology, computational modeling, and biomedical applications.
Project Overview:
Students will develop and analyze a constraint-based metabolic model using Python-based tools (COBRApy) to simulate metabolism in cancer cells or a pathogen (e.g., Mycobacterium tuberculosis, Plasmodium falciparum). The goal is to predict metabolic vulnerabilities and propose potential drug targets.